Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models

Staphylococcus aureus is one of the most common pathogens for hospital-acquired and community-acquired infections. Methicillin-resistant S. aureus (MRSA) formed biofilms in wounds are difficult to treat with conventional antibiotics. By targeting FabB/FabF of bacterial fatty acid synthases, platensi...

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Publicat a:Mol Pharm
Autors principals: Su, Meng, Qiu, Lin, Deng, Youchao, Ruiz, Claudia H., Rudolf, Jeffrey D., Dong, Liao-Bin, Feng, Xueqiong, Cameron, Michael D., Shen, Ben, Duan, Yanwen, Huang, Yong
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763203/
https://ncbi.nlm.nih.gov/pubmed/31244223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00293
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