The Brain Metabolite Kynurenic Acid Inhibits α7 Nicotinic Receptor Activity and Increases Non-α7 Nicotinic Receptor Expression: Physiopathological Implications

The tryptophan metabolite kynurenic acid (KYNA) has long been recognized as an NMDA receptor antagonist. Here, interactions between KYNA and the nicotinic system in the brain were investigated using the patch-clamp technique and HPLC. In the electrophysiological studies, agonists were delivered via...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Hilmas, Corey, Pereira, Edna F. R., Alkondon, Manickavasagom, Rassoulpour, Arash, Schwarcz, Robert, Albuquerque, Edson X.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2001
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762893/
https://ncbi.nlm.nih.gov/pubmed/11567036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-19-07463.2001
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