Regulation of GABAergic Inputs to CA1 Pyramidal Neurons by Nicotinic Receptors and Kynurenic Acid

Impaired α7 nicotinic acetylcholine receptor (nAChR) function and GABAergic transmission in the hippocampus and elevated brain levels of kynurenic acid (KYNA), an astrocyte-derived metabolite of the kynurenine pathway, are key features of schizophrenia. KYNA acts as a noncompetitive antagonist with...

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Bibliographic Details
Main Authors: Banerjee, Jyotirmoy, Alkondon, Manickavasagom, Pereira, Edna F. R., Albuquerque, Edson X.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2012
Subjects:
Cellular and Molecular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336820/
https://ncbi.nlm.nih.gov/pubmed/22344459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.189860
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