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Regulation of GABAergic Inputs to CA1 Pyramidal Neurons by Nicotinic Receptors and Kynurenic Acid

Impaired α7 nicotinic acetylcholine receptor (nAChR) function and GABAergic transmission in the hippocampus and elevated brain levels of kynurenic acid (KYNA), an astrocyte-derived metabolite of the kynurenine pathway, are key features of schizophrenia. KYNA acts as a noncompetitive antagonist with...

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Detalhes bibliográficos
Main Authors: Banerjee, Jyotirmoy, Alkondon, Manickavasagom, Pereira, Edna F. R., Albuquerque, Edson X.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336820/
https://ncbi.nlm.nih.gov/pubmed/22344459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.189860
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