Local Injection of Endothelin-1 Produces Pain-Like Behavior and Excitation of Nociceptors in Rats

Neurobehavioral and neurophysiological actions of the peptide endothelin-1 (ET-1) were investigated after subcutaneous plantar hindpaw injections in adult male Sprague Dawley rats. Hindpaw flinching developed within minutes after ET-1 (8–16 nmol) injection, peaked at 30 min, lasted for 60 min, and w...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Gokin, Alexander P., Fareed, Moin U., Pan, Hui-Lin, Hans, Guy, Strichartz, Gary R., Davar, Gudarz
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2001
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762859/
https://ncbi.nlm.nih.gov/pubmed/11438612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-14-05358.2001
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