Constitutive “Light” Adaptation in Rods from G90D Rhodopsin: A Mechanism for Human Congenital Nightblindness without Rod Cell Loss

A dominant form of human congenital nightblindness is caused by a gly90→asp (G90D) mutation in rhodopsin. G90D has been shown to activate the phototransduction cascade in the absence of lightin vitro. Such constitutive activity of G90D rhodopsinin vivo would desensitize rod photoreceptors and lead t...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Sieving, Paul A., Fowler, Michael L., Bush, Ronald A., Machida, Shigeki, Calvert, Peter D., Green, Daniel G., Makino, Clint L., McHenry, Christina L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2001
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762654/
https://ncbi.nlm.nih.gov/pubmed/11466416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-15-05449.2001
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