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Protein Kinase C-Mediated Inhibition of μ-Opioid Receptor Internalization and Its Involvement in the Development of Acute Tolerance to Peripheral μ-Agonist Analgesia
We investigated the role of protein kinase C (PKC) in cell μ-opioid receptor (MOR) internalization and MOR-mediated acute tolerance in vivo. When Chinese hamster ovary cells expressing MOR were exposed to [D-Ala(2),MePhe(4),Gly-ol(5)]-enkephalin (DAMGO), receptor internalization was observed at 30 m...
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| Publicado en: | J Neurosci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Society for Neuroscience
2001
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6762572/ https://ncbi.nlm.nih.gov/pubmed/11312280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-09-02967.2001 |
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