Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7

To study the role of mGlu7 receptors (mGluR7), we used homologous recombination to generate mice lacking this metabotropic receptor subtype (mGluR7(−/−)). After the serendipitous discovery of a sensory stimulus-evoked epileptic phenotype, we tested two convulsant drugs, pentylenetetrazole (PTZ) and...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Sansig, Gilles, Bushell, Trevor J., Clarke, Vernon R. J., Rozov, Andrei, Burnashev, Nail, Portet, Chantal, Gasparini, Fabrizio, Schmutz, Markus, Klebs, Klaus, Shigemoto, Ryuichi, Flor, Peter J., Kuhn, Rainer, Knoepfel, Thomas, Schroeder, Markus, Hampson, David R., Collett, Valerie J., Zhang, Congxiao, Duvoisin, Robert M., Collingridge, Graham L., van der Putten, Herman
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762269/
https://ncbi.nlm.nih.gov/pubmed/11698585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-22-08734.2001
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