Inhibition of CorA-Dependent Magnesium Homeostasis Is Cidal in Mycobacterium tuberculosis

Mechanisms of magnesium homeostasis in Mycobacterium tuberculosis are poorly understood. Here, we describe the characterization of a pyrimidinetrione amide scaffold that disrupts magnesium homeostasis in the pathogen by direct binding to the CorA Mg(2+)/Co(2+) transporter. Mutations in domains of Co...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Park, Yumi, Ahn, Yong-Mo, Jonnala, Surendranadha, Oh, Sangmi, Fisher, Julia M., Goodwin, Michael B., Ioerger, Thomas R., Via, Laura E., Bayliss, Tracy, Green, Simon R., Ray, Peter C., Wyatt, Paul G., Barry, Clifton E., Boshoff, Helena I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761525/
https://ncbi.nlm.nih.gov/pubmed/31383669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01006-19
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