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GRK2 promotes growth of medulloblastoma cells and protects them from chemotherapy-induced apoptosis

G-protein coupled receptor kinase 2 (GRK2; ADRBK1, BARK1) is most known as a regulator of G-protein coupled receptors. However, GRK2 also has other functions. Medulloblastomas are the most common malignant brain cancers in children. GRK2 has not been implicated in medulloblastoma biology. Here we re...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Pathania, Anup S., Ren, Xiuhai, Mahdi, Min Y., Shackleford, Gregory M., Erdreich-Epstein, Anat
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761358/
https://ncbi.nlm.nih.gov/pubmed/31554835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50157-5
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