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GRK2 promotes growth of medulloblastoma cells and protects them from chemotherapy-induced apoptosis

G-protein coupled receptor kinase 2 (GRK2; ADRBK1, BARK1) is most known as a regulator of G-protein coupled receptors. However, GRK2 also has other functions. Medulloblastomas are the most common malignant brain cancers in children. GRK2 has not been implicated in medulloblastoma biology. Here we re...

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Publicat a:Sci Rep
Autors principals: Pathania, Anup S., Ren, Xiuhai, Mahdi, Min Y., Shackleford, Gregory M., Erdreich-Epstein, Anat
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761358/
https://ncbi.nlm.nih.gov/pubmed/31554835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50157-5
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