Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract

Innate immune responses to Zika virus (ZIKV) are dampened in the lower female reproductive tract (LFRT) compared to other tissues, but the mechanism that underlies this vulnerability is poorly understood. Using tissues from uninfected and vaginally ZIKV-infected macaques and mice, we show that low b...

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Publicado en:Nat Commun
Main Authors: Khan, Shahzada, Lew, Irene, Wu, Frank, Fritts, Linda, Fontaine, Krystal A., Tomar, Sakshi, Trapecar, Martin, Shehata, Hesham M., Ott, Melanie, Miller, Christopher J., Sanjabi, Shomyseh
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761111/
https://ncbi.nlm.nih.gov/pubmed/31554802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12371-7
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