Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract

Innate immune responses to Zika virus (ZIKV) are dampened in the lower female reproductive tract (LFRT) compared to other tissues, but the mechanism that underlies this vulnerability is poorly understood. Using tissues from uninfected and vaginally ZIKV-infected macaques and mice, we show that low b...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Khan, Shahzada, Lew, Irene, Wu, Frank, Fritts, Linda, Fontaine, Krystal A., Tomar, Sakshi, Trapecar, Martin, Shehata, Hesham M., Ott, Melanie, Miller, Christopher J., Sanjabi, Shomyseh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761111/
https://ncbi.nlm.nih.gov/pubmed/31554802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12371-7
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