Stable pantothenamide bioisosteres: novel antibiotics for Gram-positive bacteria

The emergence of multidrug resistant bacteria has prioritized the development of new antibiotics. N-substituted pantothenamides, analogs of the natural compound pantetheine, were reported to target bacterial coenzyme A biosynthesis, but these compounds have never reached the clinic due to their inst...

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Pubblicato in:J Antibiot (Tokyo)
Autori principali: Jansen, Patrick A. M., van der Krieken, Danique A., Botman, Peter N. M., Blaauw, Richard H., Cavina, Lorenzo, Raaijmakers, Eline M., de Heuvel, Erik, Sandrock, Julia, Pennings, Lian J., Hermkens, Pedro H. H., Zeeuwen, Patrick L. J. M., Rutjes, Floris P. J. T., Schalkwijk, Joost
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760626/
https://ncbi.nlm.nih.gov/pubmed/31171848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41429-019-0196-6
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