Novel pantothenate derivatives for anti-malarial chemotherapy

BACKGROUND: A number of synthetic pantothenate derivatives, such as pantothenamides, are known to inhibit the growth of the human malaria parasite Plasmodium falciparum, by interfering with the parasite Coenzyme A (CoA) biosynthetic pathway. The clinical use of pantothenamides is limited by their se...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: Pett, Helmi E, Jansen, Patrick AM, Hermkens, Pedro HH, Botman, Peter NM, Beuckens-Schortinghuis, Christien A, Blaauw, Richard H, Graumans, Wouter, van de Vegte-Bolmer, Marga, Koolen, Karin MJ, Rutjes, Floris PJT, Dechering, Koen J, Sauerwein, Robert W, Schalkwijk, Joost
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425855/
https://ncbi.nlm.nih.gov/pubmed/25927675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-015-0673-8
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