Bone Marrow Stromal Cells Transcriptionally Repress ESR1 but Cannot Overcome Constitutive ESR1 Mutant Activity

Estrogen receptor α (ER) is the target of endocrine therapies in ER-positive breast cancer (BC), but their therapeutic effectiveness diminishes with disease progression. Most metastatic BCs retain an ER-positive status, but ER expression levels are reduced. We asked how the bone tumor microenvironme...

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Publicat a:Endocrinology
Autors principals: Lung, David K, Warrick, Jay W, Hematti, Peiman, Callander, Natalie S, Mark, Christina J, Miyamoto, Shigeki, Alarid, Elaine T
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2019
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Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760314/
https://ncbi.nlm.nih.gov/pubmed/31504407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2019-00299
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