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Cancer immunotherapy with T cells carrying bispecific receptors that mimic antibodies

Tumors are inherently heterogeneous in antigen expression and escape from immune surveillance due to antigen loss remains one of the limitations of targeted immunotherapy. Despite the clinical use of adoptive therapy with chimeric antigen receptor (CAR)–redirected T cells in lymphoblastic leukemia,...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Immunol Res
Hauptverfasser: Ahn, Sarah, Li, Jingjing, Sun, Chuang, Gao, Keliang, Hirabayashi, Koichi, Li, Hongxia, Savoldo, Barbara, Liu, Rihe, Dotti, Gianpietro
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760241/
https://ncbi.nlm.nih.gov/pubmed/30842091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0636
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