Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

RNA-based therapeutics hold great promise for treating diseases and lipid nanoparticles (LNPs) represent the most advanced platform for RNA delivery. However, the fate of the LNP-mRNA after endosome-engulfing and escape from the autophagy-lysosomal pathway remains unclear. To investigate this, mRNA...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Maugeri, Marco, Nawaz, Muhammad, Papadimitriou, Alexandros, Angerfors, Annelie, Camponeschi, Alessandro, Na, Manli, Hölttä, Mikko, Skantze, Pia, Johansson, Svante, Sundqvist, Martina, Lindquist, Johnny, Kjellman, Tomas, Mårtensson, Inga-Lill, Jin, Tao, Sunnerhagen, Per, Östman, Sofia, Lindfors, Lennart, Valadi, Hadi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760118/
https://ncbi.nlm.nih.gov/pubmed/31551417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12275-6
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