Synthesis and Inhibition Evaluation of New Benzyltetrahydroprotoberberine Alkaloids Designed as Acetylcholinesterase Inhibitors

Secondary metabolites from natural products are a potential source of acetylcholinesterase inhibitors (AChEIs), which is a key enzyme in the treatment of many neurodegenerative diseases. Inspired by the reported activities of isoquinoline-derivative alkaloids herein we report the design, one step sy...

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Detalles Bibliográficos
Publicado en:Front Chem
Main Authors: de Lima, Bruna R., Lima, Juliana M., Maciel, Jéssica B., Valentim, Carolina Q., Nunomura, Rita de Cássia S., Lima, Emerson S., Koolen, Hector H. F., de Souza, Afonso Duarte L, Pinheiro, Maria Lúcia B., Cass, Quezia B., da Silva, Felipe Moura A.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Chemistry
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760013/
https://ncbi.nlm.nih.gov/pubmed/31620424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00629
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