Synthesis and Inhibition Evaluation of New Benzyltetrahydroprotoberberine Alkaloids Designed as Acetylcholinesterase Inhibitors

Secondary metabolites from natural products are a potential source of acetylcholinesterase inhibitors (AChEIs), which is a key enzyme in the treatment of many neurodegenerative diseases. Inspired by the reported activities of isoquinoline-derivative alkaloids herein we report the design, one step sy...

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Vydáno v:Front Chem
Hlavní autoři: de Lima, Bruna R., Lima, Juliana M., Maciel, Jéssica B., Valentim, Carolina Q., Nunomura, Rita de Cássia S., Lima, Emerson S., Koolen, Hector H. F., de Souza, Afonso Duarte L, Pinheiro, Maria Lúcia B., Cass, Quezia B., da Silva, Felipe Moura A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760013/
https://ncbi.nlm.nih.gov/pubmed/31620424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00629
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