Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia‐Reperfusion Injury

BACKGROUND: α Carboxyl terminus 1 (αCT1) is a 25–amino acid therapeutic peptide incorporating the zonula occludens‐1 (ZO‐1)–binding domain of connexin 43 (Cx43) that is currently in phase 3 clinical testing on chronic wounds. In mice, we reported that αCT1 reduced arrhythmias after cardiac injury, a...

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Vydáno v:J Am Heart Assoc
Hlavní autoři: Jiang, Jingbo, Hoagland, Daniel, Palatinus, Joseph A., He, Huamei, Iyyathurai, Jegan, Jourdan, L. Jane, Bultynck, Geert, Wang, Zhen, Zhang, Zhiwei, Schey, Kevin, Poelzing, Steven, McGowan, Francis X., Gourdie, Robert G.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6759879/
https://ncbi.nlm.nih.gov/pubmed/31422747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.012385
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