HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection

Thioredoxin-interacting protein (Txnip) inhibits the activity of thioredoxin (Trx) to modulate inflammatory responses. The burden of inflammation caused by microbial infection is strongly associated with disease severity; however, the role of Txnip in bacterial infection remains unclear. In Group A...

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Vydáno v:Front Immunol
Hlavní autoři: Tseng, Po-Chun, Kuo, Chih-Feng, Cheng, Miao-Huei, Wan, Shu-Wen, Lin, Chiou-Feng, Chang, Chih-Peng, Lin, Yee-Shin, Wu, Jiunn-Jong, Huang, Chi-Chen, Chen, Chia-Ling
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6759821/
https://ncbi.nlm.nih.gov/pubmed/31620121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02147
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