Relative Contributions of Extracellular and Internalized Bacteria to Early Macrophage Proinflammatory Responses to Streptococcus pneumoniae

Both intracellular immune sensing and extracellular innate immune sensing have been implicated in initiating macrophage proinflammatory cytokine responses to Streptococcus pneumoniae. The S. pneumoniae capsule, a major virulence determinant, prevents phagocytosis, and we hypothesized that this would...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Periselneris, Jimstan, Ercoli, Giuseppe, Pollard, Tracey, Chimalapati, Suneeta, Camberlein, Emilie, Szylar, Gabriella, Hyams, Catherine, Tomlinson, Gillian, Petersen, Fernanda C., Floto, R. Andres, Noursadeghi, Mahdad, Brown, Jeremy S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6759765/
https://ncbi.nlm.nih.gov/pubmed/31551336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02144-19
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