An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack K(Na) Currents

Mutations in the KCNT1 (Slack, K(Na)1.1) sodium-activated potassium channel produce severe epileptic encephalopathies. Expression in heterologous systems has shown that the disease-causing mutations give rise to channels that have increased current amplitude. It is not known, however, whether such g...

詳細記述

保存先:
書誌詳細
出版年:J Neurosci
主要な著者: Quraishi, Imran H., Stern, Shani, Mangan, Kile P., Zhang, Yalan, Ali, Syed R., Mercier, Michael R., Marchetto, Maria C., McLachlan, Michael J., Jones, Eugenia M., Gage, Fred H., Kaczmarek, Leonard K.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2019
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6759030/
https://ncbi.nlm.nih.gov/pubmed/31350261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1628-18.2019
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