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The accuracy of LD Score regression as an estimator of confounding and genetic correlations in genome-wide association studies

To infer that a single-nucleotide polymorphism (SNP) either affects a phenotype or is linkage disequilibrium with a causal site, we must have some assurance that any SNP-phenotype correlation is not the result of confounding with environmental variables that also affect the trait. In this study, we...

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Pubblicato in:Genet Epidemiol
Autori principali: Lee, James J., McGue, Matt, Iacono, William G., Chow, Carson C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758917/
https://ncbi.nlm.nih.gov/pubmed/30251275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22161
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