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Caspase Inhibitors Attenuate 1-Methyl-4-Phenylpyridinium Toxicity in Primary Cultures of Mesencephalic Dopaminergic Neurons
Parkinson's disease is characterized by a loss of dopaminergic nigrostriatal neurons. This neuronal loss is mimicked by the neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)). MPP(+) toxicity is mediated through inhibition of mitochondrial complex I, decreasing ATP production, and upregulation of...
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| 出版年: | J Neurosci |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Society for Neuroscience
2002
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6758313/ https://ncbi.nlm.nih.gov/pubmed/11923429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-07-02637.2002 |
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