Caspase Inhibitors Attenuate 1-Methyl-4-Phenylpyridinium Toxicity in Primary Cultures of Mesencephalic Dopaminergic Neurons

Parkinson's disease is characterized by a loss of dopaminergic nigrostriatal neurons. This neuronal loss is mimicked by the neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)). MPP(+) toxicity is mediated through inhibition of mitochondrial complex I, decreasing ATP production, and upregulation of...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Bilsland, James, Roy, Sophie, Xanthoudakis, Steve, Nicholson, Donald W., Han, Yongxin, Grimm, Erich, Hefti, Franz, Harper, Sarah J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2002
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758313/
https://ncbi.nlm.nih.gov/pubmed/11923429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-07-02637.2002
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