A Dual Role for the SDF-1/CXCR4 Chemokine Receptor System in Adult Brain: Isoform-Selective Regulation of SDF-1 Expression Modulates CXCR4-Dependent Neuronal Plasticity and Cerebral Leukocyte Recruitment after Focal Ischemia

The chemoattractant stromal cell-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor 4 (CXCR4) are key modulators of immune function. In the developing brain, SDF-1 is crucial for neuronal guidance; however, cerebral functions of SDF-1/CXCR4 in adulthood are unclear. Here, we examine th...

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Vydáno v:J Neurosci
Hlavní autoři: Stumm, Ralf K., Rummel, Jutta, Junker, Vera, Culmsee, Carsten, Pfeiffer, Manuela, Krieglstein, Josef, Höllt, Volker, Schulz, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2002
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757949/
https://ncbi.nlm.nih.gov/pubmed/12122049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-14-05865.2002
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