An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage

Chronic systemic complex I inhibition caused by rotenone exposure induces features of Parkinson's disease (PD) in rats, including selective nigrostriatal dopaminergic degeneration and formation of ubiquitin- and α-synuclein-positive inclusions (Betarbet et al., 2000). To determine underlying me...

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Publicado en:J Neurosci
Autores principales: Sherer, Todd B., Betarbet, Ranjita, Stout, Amy K., Lund, Serena, Baptista, Melisa, Panov, Alexander V., Cookson, Mark R., Greenamyre, J. Timothy
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2002
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757862/
https://ncbi.nlm.nih.gov/pubmed/12177198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-16-07006.2002
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