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Activation of Rac GTPase by p75 Is Necessary for c-jun N-Terminal Kinase-Mediated Apoptosis

The neurotrophin receptor p75 can induce apoptosis both in vitro and in vivo. The mechanisms by which p75 induces apoptosis have remained mostly unknown. Here, we report that p75 activates Rac GTPase, which in turn activates c-junN-terminal kinase (JNK), including an injury-specific JNK3, in an NGF-...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Harrington, Anthony W., Kim, Ju Young, Yoon, Sung Ok
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757583/
https://ncbi.nlm.nih.gov/pubmed/11756498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-01-00156.2002
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