Increased sensitivity to apoptosis induced by methotrexate is mediated by Jun N-terminal kinase

OBJECTIVE: Low-dose methotrexate [MTX] is an effective therapy for rheumatoid arthritis yet its mechanism of action is incompletely understood. Here, we explored induction of apoptosis by MTX. METHODS: We employed flow cytometry to assess changes in levels of intracellular proteins, reactive oxygen...

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Hauptverfasser: Spurlock, Charles F., Aune, Zachary T., Tossberg, John T., Collins, Patrick L., Aune, Jessica P., Huston, Joseph W., Crooke, Philip S., Olsen, Nancy J., Aune, Thomas M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165146/
https://ncbi.nlm.nih.gov/pubmed/21618198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30457
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