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Increased sensitivity to apoptosis induced by methotrexate is mediated by Jun N-terminal kinase
OBJECTIVE: Low-dose methotrexate [MTX] is an effective therapy for rheumatoid arthritis yet its mechanism of action is incompletely understood. Here, we explored induction of apoptosis by MTX. METHODS: We employed flow cytometry to assess changes in levels of intracellular proteins, reactive oxygen...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3165146/ https://ncbi.nlm.nih.gov/pubmed/21618198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30457 |
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