Methotrexate increases expression of cell cycle checkpoint genes via Jun-N-terminal kinase activation

OBJECTIVE: To assess defects in expression of critical cell cycle checkpoint genes and proteins in subjects with rheumatoid arthritis relative to presence or absence of methotrexate medication and assess the role of Jun N-terminal kinase in methotrexate induction of these genes. METHODS: Flow cytome...

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Bibliographic Details
Main Authors: Spurlock, Charles F., Tossberg, John T., Fuchs, Howard A., Olsen, Nancy J., Aune, Thomas M.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310965/
https://ncbi.nlm.nih.gov/pubmed/22183962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34342
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