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Methotrexate increases expression of cell cycle checkpoint genes via Jun-N-terminal kinase activation

OBJECTIVE: To assess defects in expression of critical cell cycle checkpoint genes and proteins in subjects with rheumatoid arthritis relative to presence or absence of methotrexate medication and assess the role of Jun N-terminal kinase in methotrexate induction of these genes. METHODS: Flow cytome...

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Bibliografski detalji
Glavni autori: Spurlock, Charles F., Tossberg, John T., Fuchs, Howard A., Olsen, Nancy J., Aune, Thomas M.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310965/
https://ncbi.nlm.nih.gov/pubmed/22183962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34342
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