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Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader
[Image: see text] SGK3 is a PX domain containing protein kinase activated at endosomes downstream of class 1 and 3 PI3K family members by growth factors and oncogenic mutations. SGK3 plays a key role in mediating resistance of breast cancer cells to class 1 PI3K or Akt inhibitors, by substituting fo...
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| Gepubliceerd in: | ACS Chem Biol |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American
Chemical
Society
2019
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6757289/ https://ncbi.nlm.nih.gov/pubmed/31461270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00505 |
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