Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

[Image: see text] SGK3 is a PX domain containing protein kinase activated at endosomes downstream of class 1 and 3 PI3K family members by growth factors and oncogenic mutations. SGK3 plays a key role in mediating resistance of breast cancer cells to class 1 PI3K or Akt inhibitors, by substituting fo...

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Vydáno v:ACS Chem Biol
Hlavní autoři: Tovell, Hannah, Testa, Andrea, Zhou, Houjiang, Shpiro, Natalia, Crafter, Claire, Ciulli, Alessio, Alessi, Dario R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757289/
https://ncbi.nlm.nih.gov/pubmed/31461270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00505
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