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Differential Recognition of Diet-Derived Neu5Gc-Neoantigens on Glycan Microarrays by Carbohydrate-Specific Pooled Human IgG and IgA Antibodies

Sialic acids (Sias) cover vertebrate cell surface glycans. N-Acetylneuraminic acid (Neu5Ac) and its hydroxylated form N-glycolylneuraminic acid (Neu5Gc) are common Sia in mammals. Humans cannot synthesize Neu5Gc but accumulate it on cells through red-meat rich diets, generating numerous immunogenic...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Main Authors: Leviatan Ben-Arye, Shani, Schneider, Christoph, Yu, Hai, Bashir, Salam, Chen, Xi, von Gunten, Stephan, Padler-Karavani, Vered
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756923/
https://ncbi.nlm.nih.gov/pubmed/30994337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.9b00273
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