Dynamic PML protein nucleolar associations with persistent DNA damage lesions in response to nucleolar stress and senescence-inducing stimuli

Diverse stress insults trigger interactions of PML with nucleolus, however, the function of these PML nucleolar associations (PNAs) remains unclear. Here we show that during induction of DNA damage-induced senescence in human non-cancerous cells, PML accumulates at the nucleolar periphery simultaneo...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Imrichova, Terezie, Hubackova, Sona, Kucerova, Alena, Kosla, Jan, Bartek, Jiri, Hodny, Zdenek, Vasicova, Pavla
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756913/
https://ncbi.nlm.nih.gov/pubmed/31493766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102248
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