Dynamic PML protein nucleolar associations with persistent DNA damage lesions in response to nucleolar stress and senescence-inducing stimuli

Diverse stress insults trigger interactions of PML with nucleolus, however, the function of these PML nucleolar associations (PNAs) remains unclear. Here we show that during induction of DNA damage-induced senescence in human non-cancerous cells, PML accumulates at the nucleolar periphery simultaneo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Aging (Albany NY)
Hauptverfasser: Imrichova, Terezie, Hubackova, Sona, Kucerova, Alena, Kosla, Jan, Bartek, Jiri, Hodny, Zdenek, Vasicova, Pavla
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756913/
https://ncbi.nlm.nih.gov/pubmed/31493766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102248
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