New role of P2X7 receptor in an Alzheimer’s disease mouse model

Extracellular aggregates of amyloid β (Aβ) peptides, which are characteristic of Alzheimer’s disease (AD), act as an essential trigger for glial cell activation and the release of ATP, leading to the stimulation of purinergic receptors, especially the P2X7 receptor (P2X7R). However, the involvement...

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Veröffentlicht in:Mol Psychiatry
Hauptverfasser: Martin, Elodie, Amar, Majid, Dalle, Carine, Youssef, Ihsen, Boucher, Céline, Le Duigou, Caroline, Brückner, Matthias, Prigent, Annick, Sazdovitch, Véronique, Halle, Annett, Kanellopoulos, Jean M., Fontaine, Bertrand, Delatour, Benoît, Delarasse, Cécile
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756107/
https://ncbi.nlm.nih.gov/pubmed/29934546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0108-3
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