mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma

EBV infection of preinvasive nasopharyngeal epithelium is believed to be an initiation step during pathogenesis of nasopharyngeal carcinoma (NPC), but the mechanisms remain poorly understood. Here we report a novel mechanism driving NPC metastasis through the EBV-encoded LMP1-mediated metabolic repr...

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Bibliografski detalji
Izdano u:Oncogene
Glavni autori: Zhang, Jun, Jia, Lin, Liu, Tengfei, Yip, Yim Ling, Tang, Wing Chung, Lin, Weitao, Deng, Wen, Lo, Kwok Wai, You, Chanping, Lung, Maria Li, Lung, Hong Lok, Cheung, Annie Lai-Man, Tsao, Sai Wah, Tsang, Chi Man
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756087/
https://ncbi.nlm.nih.gov/pubmed/30745576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0749-y
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