mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma

EBV infection of preinvasive nasopharyngeal epithelium is believed to be an initiation step during pathogenesis of nasopharyngeal carcinoma (NPC), but the mechanisms remain poorly understood. Here we report a novel mechanism driving NPC metastasis through the EBV-encoded LMP1-mediated metabolic repr...

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Publicado en:Oncogene
Autores principales: Zhang, Jun, Jia, Lin, Liu, Tengfei, Yip, Yim Ling, Tang, Wing Chung, Lin, Weitao, Deng, Wen, Lo, Kwok Wai, You, Chanping, Lung, Maria Li, Lung, Hong Lok, Cheung, Annie Lai-Man, Tsao, Sai Wah, Tsang, Chi Man
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756087/
https://ncbi.nlm.nih.gov/pubmed/30745576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0749-y
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