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Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness
The global downregulation of microRNAs (miRNAs) is emerging as a common hallmark of cancer. However, the mechanisms underlying this phenomenon are not well known. We identified that the oncogenic miR-146b-5p attenuates miRNA biosynthesis by targeting DICER1 and reducing its expression. DICER1 overex...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6755984/ https://ncbi.nlm.nih.gov/pubmed/30967628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0804-8 |
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