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Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness

The global downregulation of microRNAs (miRNAs) is emerging as a common hallmark of cancer. However, the mechanisms underlying this phenomenon are not well known. We identified that the oncogenic miR-146b-5p attenuates miRNA biosynthesis by targeting DICER1 and reducing its expression. DICER1 overex...

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Bibliografiske detaljer
Udgivet i:Oncogene
Main Authors: Ramírez-Moya, Julia, Wert-Lamas, León, Riesco-Eizaguirre, Garcilaso, Santisteban, Pilar
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755984/
https://ncbi.nlm.nih.gov/pubmed/30967628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0804-8
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