Light-based control of metabolic flux through assembly of synthetic organelles

To maximize a desired product, metabolic engineers typically express enzymes to high, constant levels. Yet permanent pathway activation can have undesirable consequences including competition with essential pathways and accumulation of toxic intermediates. Faced with similar challenges, natural meta...

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Bibliographic Details
Published in:Nat Chem Biol
Main Authors: Zhao, Evan M., Suek, Nathan, Wilson, Max Z., Dine, Elliot, Pannucci, Nicole L., Gitai, Zemer, Avalos, José L., Toettcher, Jared E.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755918/
https://ncbi.nlm.nih.gov/pubmed/31086330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0284-8
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