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ErbB3-binding protein 1 (EBP1) represses HNF4α-mediated transcription and insulin secretion in pancreatic β-cells

HNF4α (hepatocyte nuclear factor 4α) is one of the master regulators of pancreatic β-cell development and function, and mutations in the HNF4α gene are well-known monogenic causes of diabetes. As a member of the nuclear receptor family, HNF4α exerts its gene regulatory function through various molec...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Han, Eun Hee, Singh, Puja, Lee, In-Kyu, Urrutia, Raul, Chi, Young-In
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755798/
https://ncbi.nlm.nih.gov/pubmed/31362984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009558
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