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Structural characterization of Class 2 OLD family nucleases supports a two-metal catalysis mechanism for cleavage

Overcoming lysogenization defect (OLD) proteins constitute a family of uncharacterized nucleases present in bacteria, archaea, and some viruses. These enzymes contain an N-terminal ATPase domain and a C-terminal Toprim domain common amongst replication, recombination, and repair proteins. The in viv...

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Podrobná bibliografie
Vydáno v:Nucleic Acids Res
Hlavní autoři: Schiltz, Carl J, Lee, April, Partlow, Edward A, Hosford, Christopher J, Chappie, Joshua S
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755086/
https://ncbi.nlm.nih.gov/pubmed/31400118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz703
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