Structural insight into multistage inhibition of CRISPR-Cas12a by AcrVA4

Prokaryotes possess CRISPR-Cas systems to exclude parasitic predators, such as phages and mobile genetic elements (MGEs). These predators, in turn, encode anti-CRISPR (Acr) proteins to evade the CRISPR-Cas immunity. Recently, AcrVA4, an Acr protein inhibiting the CRISPR-Cas12a system, was shown to d...

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Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Peng, Ruchao, Li, Zhiteng, Xu, Ying, He, Shaoshuai, Peng, Qi, Wu, Lian-ao, Wu, Ying, Qi, Jianxun, Wang, Peiyi, Shi, Yi, Gao, George F.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754591/
https://ncbi.nlm.nih.gov/pubmed/31467167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909400116
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