Cell-Specific Loss of SNAP25 from Cortical Projection Neurons Allows Normal Development but Causes Subsequent Neurodegeneration

Synaptosomal associated protein 25 kDa (SNAP25) is an essential component of the SNARE complex regulating synaptic vesicle fusion. SNAP25 deficiency has been implicated in a variety of cognitive disorders. We ablated SNAP25 from selected neuronal populations by generating a transgenic mouse (B6-Snap...

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Publicado en:Cereb Cortex
Main Authors: Hoerder-Suabedissen, Anna, Korrell, Kim V, Hayashi, Shuichi, Jeans, Alexander, Ramirez, Denise M O, Grant, Eleanor, Christian, Helen C, Kavalali, Ege T, Wilson, Michael C, Molnár, Zoltán
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754517/
https://ncbi.nlm.nih.gov/pubmed/29850799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhy127
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