Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage

Supplementation with the NAD(+) precursor nicotinamide riboside (NR) ameliorates and prevents a broad array of metabolic and aging disorders in mice. However, little is known about the physiological role of endogenous NR metabolism. We have previously shown that NR kinase 1 (NRK1) is rate-limiting a...

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Publicat a:Nat Commun
Autors principals: Sambeat, Audrey, Ratajczak, Joanna, Joffraud, Magali, Sanchez-Garcia, José L., Giner, Maria P., Valsesia, Armand, Giroud-Gerbetant, Judith, Valera-Alberni, Miriam, Cercillieux, Angelique, Boutant, Marie, Kulkarni, Sameer S., Moco, Sofia, Canto, Carles
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754455/
https://ncbi.nlm.nih.gov/pubmed/31541116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12262-x
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