Preclinical pharmacodynamic and pharmacokinetic characterization of the major metabolites of cariprazine

INTRODUCTION: : Cariprazine, a dopamine D(3)-preferring D(3)/D(2) receptor partial agonist and serotonin 5-HT(1A) receptor partial agonist, has two major human metabolites, desmethyl-cariprazine (DCAR) and didesmethyl-cariprazine (DDCAR). The metabolite pharmacology was profiled to understand the co...

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Bibliografiske detaljer
Udgivet i:Drug Des Devel Ther
Main Authors: Kiss, Béla, Némethy, Zsolt, Fazekas, Károly, Kurkó, Dalma, Gyertyán, István, Sághy, Katalin, Laszlovszky, István, Farkas, Bence, Kirschner, Norbert, Bolf-Terjéki, Etelka, Balázs, Ottilia, Lendvai, Balázs
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2019
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754336/
https://ncbi.nlm.nih.gov/pubmed/31571826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S188760
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