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Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in dsRNA Response
Viral and endogenous double-stranded RNA (dsRNA) is a potent trigger for programmed RNA degradation by 2–5A/RNase L complex in cells of all mammals. This 2–5A-mediated decay (2–5AMD) is a conserved stress response switching global protein synthesis from homeostasis to production of interferons (IFNs...
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| Publicado en: | Mol Cell |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6754276/ https://ncbi.nlm.nih.gov/pubmed/31494033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.027 |
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