Single-molecule detection of deoxyribonucleoside triphosphates in microdroplets

A new approach to single-molecule DNA sequencing in which dNTPs, released by pyrophosphorolysis from the strand to be sequenced, are captured in microdroplets and read directly could have substantial advantages over current sequence-by-synthesis methods; however, there is no existing method sensitiv...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Breiner, Boris, Johnson, Kerr, Stolarek, Magdalena, Silva, Ana-Luisa, Negrea, Aurel, Bell, Neil M, Isaac, Tom H, Dethlefsen, Mark, Chana, Jasmin, Ibbotson, Lindsey A, Palmer, Rebecca N, Bush, James, Dunning, Alexander J, Love, David M, Pachoumi, Olympia, Kelly, Douglas J, Shibahara, Aya, Wu, Mei, Sosna, Maciej, Dear, Paul H, Tolle, Fabian, Petrini, Edoardo, Amasio, Michele, Shelford, Leigh R, Saavedra, Monica S, Sheridan, Eoin, Kuleshova, Jekaterina, Podd, Gareth J, Balmforth, Barnaby W, Frayling, Cameron A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753480/
https://ncbi.nlm.nih.gov/pubmed/31318971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz611
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