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DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation
Most human cancers acquire mutations causing defects in the p53 signaling pathway. The tumor suppressor p53 becomes activated in response to genotoxic stress and is essential for arresting the cell cycle to facilitate DNA repair or to initiate apoptosis. p53-induced cell cycle-arrest is mediated by...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6753476/ https://ncbi.nlm.nih.gov/pubmed/31400114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz635 |
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