DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation

Most human cancers acquire mutations causing defects in the p53 signaling pathway. The tumor suppressor p53 becomes activated in response to genotoxic stress and is essential for arresting the cell cycle to facilitate DNA repair or to initiate apoptosis. p53-induced cell cycle-arrest is mediated by...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Uxa, Sigrid, Bernhart, Stephan H, Mages, Christina F S, Fischer, Martin, Kohler, Robin, Hoffmann, Steve, Stadler, Peter F, Engeland, Kurt, Müller, Gerd A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Gene regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753476/
https://ncbi.nlm.nih.gov/pubmed/31400114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz635
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