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In vitro metabolic zonation through oxygen gradient on a chip

Among the multiple metabolic signals involved in the establishment of the hepatic zonation, oxygen could play a key role. Indeed, depending on hepatocyte position in the hepatic lobule, gene expression and metabolism are differently affected by the oxygen gradient present across the lobule. The aim...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tonon, Federica, Giobbe, Giovanni Giuseppe, Zambon, Alessandro, Luni, Camilla, Gagliano, Onelia, Floreani, Annarosa, Grassi, Gabriele, Elvassore, Nicola
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753109/
https://ncbi.nlm.nih.gov/pubmed/31537830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49412-6
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